Expansion of the CGG repeat in fragile X in the FMR1 gene depends on the sex of the offspring.

Article

Expansion of the CGG repeat in fragile X in the FMR1 gene depends on the sex of the offspring.

American journal of human genetics - 1 Dec 1995

Loesch D Z, Huggins R, Petrovic V, Slater H

Abstract excerpt

Analysis of 139 mother-to-offspring transmissions of fragile X CGG triplet repeats revealed that the repeat expansion is enhanced in mother-to-son transmissions compared with mother-to-daughter transmissions. Evidence has been based on analysis of mother-offspring differences in the size of repea...

Topics

Female
Fragile X Mental Retardation Protein
Fragile X Syndrome
Humans
Male
Mutation
Nerve Tissue Proteins
RNA-Binding Proteins
Repetitive Sequences, Nucleic Acid
Sex Distribution

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