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Article

FMR1 CGG-repeat instability in single sperm and lymphocytes of fragile-X premutation males.

American journal of human genetics - 1 Sept 1999

Nolin S L, Houck G E, Gargano A D, Blumstein H, Dobkin C S, Brown W T

Abstract excerpt

To determine the meiotic instability of the CGG-triplet repeat in the fragile-X gene, FMR1, we examined the size of the repeat in single sperm from four premutation males. The males had CGG-repeat sizes of 68, 75, 78, and 100, as determined in peripheral blood samples. All samples showed a broad range of variations, with expansions more common than contractions. Examination of single lymphocytes indicated that...

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Share to Fragile X Mental Retardation Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10441574
DOI: 10.1086/302543
PMCID: PMC1377974

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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FMR1 CGG-repeat instability in single sperm and lymphocytes of fragile-X premutation males.PMID 10441574Read ↗

The effect of FMR1 CGG repeat interruptions on mutation frequency as measured by sperm typing.Semantic proximity Read ↗

Mechanisms of the FMR1 Repeat Instability: How Does the CGG Sequence Expand?Semantic proximity Read ↗

Analysis of germline variation at the FMR1 CGG repeat shows variation in the normal-premutated borderline range.Semantic proximity Read ↗

Detecting AGG Interruptions in Male and Female FMR1 Premutation Carriers by Single-Molecule Sequencing.Semantic proximity Read ↗

Genetic variation and intergenerational FMR1 CGG-repeat stability in 100 unrelated three-generation families from the normal population.Semantic proximity Read ↗

Familial transmission of the FMR1 CGG repeat.Semantic proximity Read ↗

Examination of factors associated with instability of the FMR1 CGG repeat.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox.Semantic proximity Read ↗

Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1.Semantic proximity Read ↗

Analysis of a CGG sequence at the FMR-1 locus in fragile X families and in the general population.Semantic proximity Read ↗

Expansion of the CGG repeat in fragile X in the FMR1 gene depends on the sex of the offspring.Semantic proximity Read ↗

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