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Article

An ethylene-inducible component of signal transduction encoded by never-ripe.

Science (New York, N.Y.) - 15 Dec 1995

Wilkinson J Q, Lanahan M B, Yen H C, Giovannoni J J, Klee H J

Abstract excerpt

The ripening-impaired tomato mutant Never-ripe (Nr) is insensitive to the plant hormone ethylene. The gene that cosegregates with the Nr locus encodes a protein with homology to the Arabidopsis ethylene receptor ETR1 but is lacking the response regulator domain found in ETR1 and related prokaryotic two-component signal transducers. A single amino acid change in the sensor domain confers ethylene insensitivity...

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Source

Identifiers

PMID: 8525371
DOI: 10.1126/science.270.5243.1807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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An ethylene-inducible component of signal transduction encoded by never-ripe.PMID 8525371Read ↗

The tomato Never-ripe locus regulates ethylene-inducible gene expression and is linked to a homolog of the Arabidopsis ETR1 gene.Semantic proximity Read ↗

Antisense inhibition of the Nr gene restores normal ripening to the tomato Never-ripe mutant, consistent with the ethylene receptor-inhibition model.Semantic proximity Read ↗

Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling.Semantic proximity Read ↗

Comprehensive Profiling of Ethylene Response Factor Expression Identifies Ripening-Associated ERF Genes and Their Link to Key Regulators of Fruit Ripening in Tomato.Semantic proximity Read ↗

Transcriptome and selected metabolite analyses reveal multiple points of ethylene control during tomato fruit development.Semantic proximity Read ↗

Physiological and metabolic bases of increased growth in the tomato ethylene-insensitive mutant Never ripe: extending ethylene signaling functions.Semantic proximity Read ↗

Re-evaluation of the nor mutation and the role of the NAC-NOR transcription factor in tomato fruit ripening.Semantic proximity Read ↗

Ethylene insensitivity conferred by the Green-ripe and Never-ripe 2 ripening mutants of tomato.Semantic proximity Read ↗

Transcriptome analysis of rin mutant fruit and in silico analysis of promoters of differentially regulated genes provides insight into LeMADS-RIN-regulated ethylene-dependent as well as ethylene-independent aspects of ripening in tomato.Semantic proximity Read ↗

REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis.Semantic proximity Read ↗

The chimeric repressor version of an Ethylene Response Factor (ERF) family member, Sl-ERF.B3, shows contrasting effects on tomato fruit ripening.Semantic proximity Read ↗

The transcription factors RIN and NOR have both redundant and specific roles in the initiation and progression of fruit ripening.Semantic proximity Read ↗

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