Article
Mechanism for inhibition of influenza virus RNA polymerase activity by matrix protein.
Journal of virology - 1 Jan 1996
Watanabe K, Handa H, Mizumoto K, Nagata K
Abstract excerpt
Influenza virus M1 protein has been shown to inhibit the transcription catalyzed by viral ribonucleoprotein complexes isolated from virions. Here, this inhibition mechanism was studied with the recombinant M1 protein purified from Escherichia coli expressing it from cDNA. RNA mobility shift assays indicated that both soluble and aggregate forms of the recombinant M1, which were separated by the glycerol density...
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