Article
Variant mapping of the Apo(B) AT rich minisatellite. Dependence on nucleotide sequence of the copy number variations. Instability of the non-canonical alleles.
Nucleic acids research - 11 May 1993
Desmarais E, Vigneron S, Buresi C, Cambien F, Cambou J P, Roizes G
Abstract excerpt
Because of its variations in length, the AT rich Hyper-Variable Region (HVR) of the 3' end of the Apolipoprotein B gene is used as a polymorphic maker in genetic studies. It contains a SspI site in its repeated motif and we used this feature to precisely analyse the internal structure of the diff...
Topics
- Alleles
- Apolipoproteins B
- Base Composition
- Base Sequence
- Chromosome Mapping
- DNA, Satellite
- Deoxyribonucleases, Type II Site-Specific
- Gene Frequency
- Genetic Variation
- Humans
- Molecular Sequence Data
- Nucleic Acid Conformation
- Restriction Mapping