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Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family

4 May 1993

Abstract excerpt

Alzheimer's disease is a degenerative neurological disorder characterized by neural loss and brain lesions associated with plaques containing large amounts of the beta/A4 amyloid peptide. Molecular cloning of the cDNA for this peptide from human brain has shown it to be derived by proteolysis from a much larger precursor called the amyloid precursor protein (APP). The biological role of the precursor is unknown,...

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PMID: 8485127
DOI: 10.1021/bi00068a002

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