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Article

Biosynthesis of the lantibiotic subtilin is regulated by a histidine kinase/response regulator system.

Applied and environmental microbiology - 1 Jan 1993

Klein C, Kaletta C, Entian K D

Abstract excerpt

Subtilin is a lanthionine-containing peptide antibiotic (lantibiotic) which is produced by Bacillus subtilis ATCC 6633. Upstream from the structural gene of subtilin, spaS, three genes (spaB, spaT, and spaC) which are involved in the biosynthesis of subtilin have been identified (C. Klein, C. Kaletta, N. Schnell, and K.-D. Entian, Appl. Environ. Microbiol. 58:132-142, 1992). By using a hybridization probe...

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Identifiers

PMID: 8439156
DOI: 10.1128/aem.59.1.296-303.1993
PMCID: PMC202094

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