Cytogenetic analysis of uveal melanoma consistent occurrence of monosomy 3 and trisomy 8q

Abstract excerpt

BACKGROUND: The genetic alterations associated with the pathogenesis of uveal melanoma have not been determined. To address this issue, the authors performed a prospective cytogenetic study of 35 uveal melanomas, including 23 primary untreated tumors and 12 tumors that were removed after local radiation therapy. METHODS: Representative tumor tissue was processed by established methods for histopathologic and...