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Article

A nucleotide substitution in one of the beta-tubulin genes of Trichoderma viride confers resistance to the antimitotic drug methyl benzimidazole-2-yl-carbamate.

Molecular & general genetics : MGG - 1 Jul 1993

Goldman G H, Temmerman W, Jacobs D, Contreras R, Van Montagu M, Herrera-Estrella A

Abstract excerpt

We characterized a Trichoderma viride strain that is resistant to the antimitotic drug methyl benzimidazole-2-yl-carbamate (MBC). This species has two beta-tubulin genes (tub1 and tub2) and by reverse genetics we showed that a mutation in the tub2 gene confers MBC resistance in this strain. Compa...

Topics

Amino Acid Sequence
Base Sequence
Benzimidazoles
Carbamates
Cloning, Molecular
Drug Resistance, Microbial
Fungal Proteins
Fungicides, Industrial
Genes, Fungal
Histidine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Transformation, Genetic

Trichoderma

Tubulin

Tyrosine

Source

Identifiers

PMID: 8341264
DOI: 10.1007/BF00276886

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8341264-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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