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Article

Limb-girdle muscular dystrophy is closely linked to the fibrillin locus on chromosome 15.

Connective tissue research - 1 Jan 1993

Velinov M, Sarfarazi M, Young K, Hodes M E, Conneally P M, Jackson C E, Tsipouras P

Abstract excerpt

Limb-girdle Muscular Dystrophy (LGMD) is a rare form of muscular dystrophy inherited as an autosomal recessive trait. The LGMD locus was recently mapped to chromosome 15. We tested the hypothesis that fibrillin is a candidate in the etiology of the disorder by genetic linkage analysis. A large Amish kindred segregating the disorder was genotyped for two markers specific for the fibrillin gene on chromosome 15. A...

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Identifiers

PMID: 8339542
DOI: 10.3109/03008209309061962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limb-girdle muscular dystrophy is closely linked to the fibrillin locus on chromosome 15.PMID 8339542Read ↗

Mapping of a chromosome 15 region involved in limb girdle muscular dystrophy.Semantic proximity Read ↗

Localization of the fibrillin (FBN) gene to chromosome 15, band q21.1Semantic proximity Read ↗

Preferential localization of the limb-girdle muscular dystrophy type 2A gene in the proximal part of a 1-cM 15q15.1-q15.3 interval.Semantic proximity Read ↗

Genetic linkage of the Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5. The International Marfan Syndrome Collaborative Study.Semantic proximity Read ↗

Location on Chromosome 15 of the Gene Defect Causing Marfan SyndromeSemantic proximity Read ↗

Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.Semantic proximity Read ↗

A gene for autosomal recessive limb-girdle muscular dystrophy maps to chromosome 2p.Semantic proximity Read ↗

Repeat polymorphisms in human fibrillin genes on chromosome 15 (FBN1) and chromosome 5 (FBN2).Semantic proximity Read ↗

The Marfan syndrome locus: confirmation of assignment to chromosome 15 and identification of tightly linked markers at 15q15-q21.3.Semantic proximity Read ↗

Marfan Syndrome Caused by Disruption of the FBN1 Gene due to A Reciprocal Chromosome TranslocationSemantic proximity Read ↗

A primary expression map of the chromosome 15q15 region containing the recessive form of limb-girdle muscular dystrophy (LGMD2A) geneSemantic proximity Read ↗

Autosomal dominant familial spastic paraplegia: tight linkage to chromosome 15q.Semantic proximity Read ↗

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