Article
Antisperm Antibody Binding to Human Sperm Inhibits Capacitation Induced Changes in the Levels of Plasma Membrane Sterols
10 Sept 1993
Abstract excerpt
PROBLEM: Human spermatozoa express mannose ligand receptors (MLRs) over the entire head when incubated under conditions that promote loss of free cholesterol. Binding of IgA, IgG, and/or IgM head-directed anti-sperm antibodies (ASAs) to freshly isolated sperm blocks MLR expression in a dose dependent manner. METHODS: Comparison of Western blots of immunoprecipitated glycoproteins from fresh sperm exposed to ASAs...
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