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Cytokine regulation of metalloproteinase gene expression

1 Dec 1993

Abstract excerpt

Matrix metalloproteinases belong to a family of zinc-dependent enzymes capable of degrading extracellular matrix and basement membrane components. Their expression is greatly modulated by cytokines and growth factors and involves the gene products of the Fos and Jun families of oncogenes. After extra(peri)cellular activation, their activity can be further controlled by specific tissue inhibitors of...

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PMID: 8300745
DOI: 10.1002/jcb.240530404

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