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Detection of Epstein-Barr Virus Genome in Nasopharyngeal Carcinoma by In situ DNA Hybridization

1 Jan 1993

Abstract excerpt

To elucidate the possible role of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC), we investigated the EBV genome in NPC by in situ DNA hybridization using radioisotope- and and biotin-labeled EBV DNA probes. The EBV genome was detected in the tumor cells in all (100%) 60 cases, irrespective of histological type, but not in the lymphocytes. Silver grains, which reflected the copy number of the EBV...

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PMID: 8294187
DOI: 10.1159/000150327

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