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Diagnosis of Enterovirus Brain Disease in Hypogammaglobulinemic Patients by Polymerase Chain Reaction

1 Oct 1993

Abstract excerpt

CSF samples taken from three patients with primary hypogammaglobulinemia and chronic brain disease were positive for enterovirus RNA by use of a technique based on the polymerase chain reaction (PCR) to amplify viral genomic sequences. Repeated attempts to culture viruses from the CSF from these patients were unsuccessful, possibly because the patients were treated regularly with intravenous immunoglobulin, which...

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PMID: 8268346
DOI: 10.1093/clinids/17.4.657

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