Benzo(a)pyrene hydroxylase activity in yeast is mediated by P450 other than sterol 14 alpha-demethylase.

doi:10.1006/bbrc.1993.2497

Back to search

Article

Benzo(a)pyrene hydroxylase activity in yeast is mediated by P450 other than sterol 14 alpha-demethylase.

Biochemical and biophysical research communications - 15 Dec 1993

Kelly S L, Lamb D C, Baldwin B C, Kelly D E

Abstract excerpt

Benzo(a)pyrene hydroxylation has been observed in Saccharomyces cerevisiae and the role of sterol 14 alpha-demethylase (CYP51A1) in this activity has been examined by using a strain which contains a gene disruption of CYP51A1. This strain still contained P450 protein(s) with a Soret absorption ma...

Topics

Aryl Hydrocarbon Hydroxylases
Benzopyrene Hydroxylase
Crosses, Genetic
Cytochrome P-450 Enzyme System
Genes, Fungal
Genotype
Kinetics
Microsomes
Oxidoreductases
Saccharomyces cerevisiae
Sterol 14-Demethylase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.