Genetic linkage analysis, clinical features and prognosis of autosomal dominant polycystic kidney disease in Northern Ireland.

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Article

Genetic linkage analysis, clinical features and prognosis of autosomal dominant polycystic kidney disease in Northern Ireland.

The Quarterly journal of medicine - 1 Jul 1993

Wright G D, Hughes A E, Larkin K A, Doherty C C, Nevin N C

Abstract excerpt

Fifteen families with autosomal dominant polycystic kidney disease were analysed for coinheritance of the disease and DNA markers flanking the PKD1 locus. Eleven families demonstrated linkage to PKD1 markers. Two families were unlinked to the PKD1 locus (non-PKD1) and in two families the markers...

Topics

Adult
Age Distribution
Alleles
Chromosomes, Human, Pair 16
Genetic Linkage
Humans
Kidney Failure, Chronic
Lod Score
Middle Aged
Pedigree
Polycystic Kidney, Autosomal Dominant
Probability
Prognosis

Source

Open in PubMed

Identifiers

PMID: 8210302

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8210302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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