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Article

Attenuation of fungal virulence by synthetic infectious hypovirus transcripts.

Science (New York, N.Y.) - 17 Jun 1994

Chen B, Choi G H, Nuss D L

Abstract excerpt

Noninfectious, cytoplasmically transmissible viral double-stranded RNAs of the genus Hypovirus cause reduced virulence (hypovirulence) in the chestnut blight fungus Cryphonectria parasitica, providing the basis for virus-mediated biological control of a fungal disease. Synthetic transcripts corresponding to a full-length hypovirus RNA coding strand are infectious when introduced into fungal spheroplasts by...

Topics

Ascomycota
Base Sequence
DNA, Complementary
Electroporation
Molecular Sequence Data
Phenotype
Plant Diseases
RNA Viruses
RNA, Double-Stranded
RNA, Viral
Spheroplasts
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Virulence

Virus Replication

Source

Identifiers

PMID: 8209256
DOI: 10.1126/science.8209256

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8209256-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Attenuation of fungal virulence by synthetic infectious hypovirus transcripts.PMID 8209256Read ↗

Phenotypic changes associated with wild-type and mutant hypovirus RNA transfection of plant pathogenic fungi phylogenetically related to Cryphonectria parasiticaSemantic proximity Read ↗

Hypovirulence of chestnut blight fungus conferred by an infectious viral cDNA.Semantic proximity Read ↗

Infectious cDNA clone of hypovirus CHV1-Euro7: a comparative virology approach to investigate virus-mediated hypovirulence of the chestnut blight fungus Cryphonectria parasitica.Semantic proximity Read ↗

Hypoviruses and chestnut blight: exploiting viruses to understand and modulate fungal pathogenesis.Semantic proximity Read ↗

Hypovirulence-associated traits induced by a mycovirus of Cryphonectria parasitica are mimicked by targeted inactivation of a host gene.Semantic proximity Read ↗

In-Tree Behavior of Diverse Viruses Harbored in the Chestnut Blight Fungus, Cryphonectria parasitica.Semantic proximity Read ↗

A 971-bp insertion in the rns gene is associated with mitochondrial hypovirulence in a strain of Cryphonectria parasitica isolated from nature.Semantic proximity Read ↗

Trade-off between accumulation potential and transmission efficiency in hypovirus variants infecting phytopathogenic fungi.Semantic proximity Read ↗

Molecular characterization of vegetative incompatibility genes that restrict hypovirus transmission in the chestnut blight fungus Cryphonectria parasitica.Semantic proximity Read ↗

Aspergillus fumigatus dsRNA virus promotes fungal fitness and pathogenicity in the mammalian hostSemantic proximity Read ↗

Comparative analysis of alterations in host phenotype and transcript accumulation following hypovirus and mycoreovirus infections of the chestnut blight fungus Cryphonectria parasitica.Semantic proximity Read ↗

RNA Interference Strategies for Future Management of Plant Pathogenic Fungi: Prospects and ChallengesSemantic proximity Read ↗

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