Article
[Research on the correlation between DNA recombinational mutation and cancer malignancy in human colon cancers].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 May 1994
Suzuki S, Kominami R, Takada T, Yabusaki Y, Tanaka N, Tanaka S, Aizawa K, Suzuki T, Tanaka O, Hatakeyama K
Abstract excerpt
The mutagenicity of quercetin, a flavonoid, was examined by means of DNA fingerprint analysis using the Pc-1 and Pc-2 minisatellite probes that efficiently detect mutations due to recombination. Treatment of FM3A and BMT-11 tumor cells with 55 microM quercetin resulted in gain and loss of bands i...
Topics
- Aged
- Colonic Neoplasms
- DNA Mutational Analysis
- DNA Probes
- DNA, Neoplasm
- DNA, Satellite
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Recombination, Genetic