Article
[Research on the correlation between DNA recombinational mutation and cancer malignancy in human colon cancers].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 May 1994
Suzuki S, Kominami R, Takada T, Yabusaki Y, Tanaka N, Tanaka S, Aizawa K, Suzuki T, Tanaka O, Hatakeyama K
Abstract excerpt
The mutagenicity of quercetin, a flavonoid, was examined by means of DNA fingerprint analysis using the Pc-1 and Pc-2 minisatellite probes that efficiently detect mutations due to recombination. Treatment of FM3A and BMT-11 tumor cells with 55 microM quercetin resulted in gain and loss of bands in the fingerprints in both cell lines. The frequencies of the clones having undergone mutation were 9/26 and 2/11,...
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