The molecular basis of beta thalassaemia in Punjabi and Maharashtran Indians includes a multilocus aetiology involving triplicated alpha-globin loci.

doi:10.1111/j.1365-2141.1994.tb04742.x

Back to search

Article

The molecular basis of beta thalassaemia in Punjabi and Maharashtran Indians includes a multilocus aetiology involving triplicated alpha-globin loci.

British journal of haematology - 1 Feb 1994

Garewal G, Fearon C W, Warren T C, Marwaha N, Marwaha R K, Mahadik C, Kazazian H H

Abstract excerpt

We have analysed 201 beta-thalassaemia (beta-thal) genes from natives of the Punjab (156) and Maharashtra states of India and found the causative mutation in 200 of them. The most common beta-globin gene mutations differed significantly between these two groups and between these groups and Indian...

Topics

Alleles
Female
Globins
Humans
India
Male
Multigene Family
Mutation
Polymerase Chain Reaction
beta-Thalassemia

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.