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Article

[Thyroid peroxidase (TPO) gene and pathogenic TPO mutation].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994

Asakawa H

Abstract excerpt

TPO is the key enzyme involved in the thyroid hormone synthesis. The human TPO (hTPO) gene locates on chromosome 2 and consists of 17 exons and 16 introns. Compared with other peroxidases, hTPO is 42% homologous with granulocyte myeloperoxidase. Thyroid cells contain multiple TPO mRNA transcripts of various size. However, the reason is unknown. TTF-1 and TTF-2 are known to regulate TPO gene expression. Moreover,...

Topics

Amino Acid Sequence
Animals
Gene Expression Regulation, Enzymologic
Humans
Hypothyroidism
Iodide Peroxidase
Molecular Sequence Data
Mutation
RNA Splicing
RNA, Messenger
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8196171

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8196171-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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