Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Thyroid peroxidase (TPO) gene and pathogenic TPO mutation].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994

Asakawa H

Abstract excerpt

TPO is the key enzyme involved in the thyroid hormone synthesis. The human TPO (hTPO) gene locates on chromosome 2 and consists of 17 exons and 16 introns. Compared with other peroxidases, hTPO is 42% homologous with granulocyte myeloperoxidase. Thyroid cells contain multiple TPO mRNA transcripts of various size. However, the reason is unknown. TTF-1 and TTF-2 are known to regulate TPO gene expression. Moreover,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Gene Expression Regulation, Enzymologic
Share to Hypothyroidism

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Share to RNA Splicing

Share to Transcription Factors

Source

Identifiers

PMID: 8196171

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Thyroid peroxidase (TPO) gene and pathogenic TPO mutation].PMID 8196171Read ↗

Thyroid Peroxidase Gene Mutations Associated with Thyroid Disorders.Semantic proximity Read ↗

[Mutation of thyroid peroxidase gene in 35 patients with congenital hypothyroidism].Semantic proximity Read ↗

Two novel missense mutations in the thyroid peroxidase gene, R665W and G771R, result in a localization defect and cause congenital hypothyroidismSemantic proximity Read ↗

Genetics and phenomics of hypothyroidism and goiter due to TPO mutations.Semantic proximity Read ↗

[Mutations of the thyroid peroxidase gene].Semantic proximity Read ↗

Functional analysis of thyroid peroxidase gene mutations resulting in congenital hypothyroidism.Semantic proximity Read ↗

Congenital hypothyroidism caused by a unique thyroid peroxidase allele containing two mutations, C1708T and C2737T.Semantic proximity Read ↗

Congenital hypothyroidism caused by a novel homozygous mutation in the thyroid peroxidase gene.Semantic proximity Read ↗

Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter.Semantic proximity Read ↗

Mutation screening of the TPO gene in a cohort of 192 Chinese patients with congenital hypothyroidism.Semantic proximity Read ↗

Genetic Screening and Functional Analysis of Thyroid Peroxidase Variants in Chinese Patients with Congenital Hypothyroidism.Semantic proximity Read ↗

High prevalence of thyroid peroxidase gene mutations in patients with thyroid dyshormonogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.