Article
Platelet mitochondrial function in Leber's hereditary optic neuropathy.
Journal of the neurological sciences - 1 Mar 1994
Smith P R, Cooper J M, Govan G G, Harding A E, Schapira A H
Abstract excerpt
We report the effect of the 11,778 and 3460 base pair mitochondrial DNA mutations, found in Leber's hereditary optic neuropathy (LHON), on platelet mitochondrial respiratory chain enzyme activity. We measured respiratory chain enzyme activities in platelets from 4 patients with the 3460 mutation, 17 patients with the 11,778 mutation and compared them with those of 41 healthy age-matched controls. We observed a...
Topics
- Blood Platelets
- Citrate (si)-Synthase
- DNA, Mitochondrial
- Electron Transport Complex I
- Electron Transport Complex IV
- Humans
- Mitochondria
- Mutation
- NADH, NADPH Oxidoreductases
- Optic Atrophies, Hereditary
- Smoking