Tremor and zitter, causative mutant genes for epilepsy with spongiform encephalopathy in spontaneously epileptic rat (SER), are tightly linked to synaptobrevin-2 and prion protein genes, respectively.

doi:10.1006/bbrc.1994.1573

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Article

Tremor and zitter, causative mutant genes for epilepsy with spongiform encephalopathy in spontaneously epileptic rat (SER), are tightly linked to synaptobrevin-2 and prion protein genes, respectively.

Biochemical and biophysical research communications - 29 Apr 1994

Kuramoto T, Mori M, Yamada J, Serikawa T

Abstract excerpt

Spontaneously epileptic rat (SER) is a homozygote for both tremor (tm) and zitter (zi) genes and exhibits epilepsy-like seizures and spongiform encephalopathy. Genetic linkage analyses revealed that the tm and zi loci were tightly linked to the synaptobrevin-2 (Syb2) on chromosome 10 and the prion protein (Prnp) on chromosome 3, respectively. The genomic DNA sequences of Syb2 of the tm/tm (TRM) rats and exon 2 of...

Topics

Animals
Base Sequence
Chromosome Mapping
DNA
Disease Models, Animal
Epilepsy
Female
Gene Expression
Genetic Linkage
Homozygote
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Molecular Sequence Data

Mutation

Nerve Tissue Proteins

Prion Diseases

Prions

R-SNARE Proteins

Source

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Identifiers

PMID: 8179598
DOI: 10.1006/bbrc.1994.1573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8179598-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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