Vaccination against rabies: construction and characterization of SAG2, a double avirulent derivative of SADBern.

doi:10.1016/0264-410x(94)90095-7

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Article

Vaccination against rabies: construction and characterization of SAG2, a double avirulent derivative of SADBern.

Vaccine - 1 Mar 1994

Lafay F, Bénéjean J, Tuffereau C, Flamand A, Coulon P

Abstract excerpt

A double avirulent mutant was isolated from the SADBern strain of rabies virus by two successive selection steps using neutralizing anti-glycoprotein monoclonal antibodies. Both mutations affect the triplet coding for amino acid 333 of the glycoprotein. The resulting virus, called SAG2, has a glu...

Topics

Animals
Animals, Suckling
Brain
Cell Line
Female
Injections
Injections, Intramuscular
Mice
Mutation
Polymerase Chain Reaction
Rabies Vaccines
Vaccines, Attenuated

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