Article
High-affinity cytotoxic T lymphocytes after non-HLA-sharing blood transfusion--the other side of the coin.
Transplantation - 27 Apr 1994
van Twuyver E, Mooijaart R J, ten Berge I J, van der Horst A R, Wilmink J M, Claas F H, de Waal L P
Abstract excerpt
Previously, we have shown that pretransplantation blood transfusion modulates the T cell repertoire to a great extent. Patients receiving a BT from a donor sharing one HLA haplotype with the patient (HLA-sharing BT) develop CTL nonresponsiveness against cells of the BT donor and show a selective...
Topics
- Alleles
- Antibodies, Monoclonal
- Blood Group Incompatibility
- CD8 Antigens
- Down-Regulation
- HLA Antigens
- Humans
- Kidney Transplantation
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocytes, Cytotoxic
- Transfusion Reaction