Article
Biosynthesis of o-succinylbenzoic acid in Bacillus subtilis: identification of menD mutants and evidence against the involvement of the alpha-ketoglutarate dehydrogenase complex.
Journal of bacteriology - 1 May 1994
Palaniappan C, Taber H, Meganathan R
Abstract excerpt
The biosynthesis of o-succinylbenzoic acid (OSB), the first aromatic intermediate involved in the biosynthesis of menaquinone (vitamin K2) is demonstrated for the first time in the gram-positive bacterium Bacillus subtilis. Cell extracts were found to contain isochorismate synthase, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase-alpha-ketoglutarate decarboxylase and o-succinylbenzoic...
Topics
- Bacillus subtilis
- Chorismic Acid
- Cyclohexanes
- Cyclohexenes
- Ketoglutarate Dehydrogenase Complex
- Mutation
- Oxo-Acid-Lyases
- Phenylbutyrates
- Salicylates
- Subcellular Fractions
- Succinates