Article
Acid-sensitive mutants of Salmonella typhimurium identified through a dinitrophenol lethal screening strategy.
Journal of bacteriology - 1 May 1994
Foster J W, Bearson B
Abstract excerpt
Salmonella typhimurium exhibits a low-pH-inducible acid tolerance response (ATR) that can protect the adapted cell from severe acid challenge (pH 3.3). It is a two-stage system, with some proteins induced at pH 5.8 (pre-acid shock) and others induced below pH 4.5 (acid shock). The genetics of acid resistance was investigated through the use of a new screening medium. The medium contained 200 microM dinitrophenol...
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