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Article

11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.

1 May 1994

Abstract excerpt

PURPOSE: Leukemic cell characteristics were analyzed in infants less than 1 year of age with acute lymphoblastic leukemia (ALL) to determine adverse prognostic factors that might explain the poor prognosis of this group. PATIENTS AND METHODS: Treatment outcomes were analyzed according to the presenting clinical and laboratory features of 30 infants treated between May 1979 and April 1993. A stepwise multivariate...

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Identifiers

PMID: 8164041
DOI: 10.1200/jco.1994.12.5.909

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Related research

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Research trail→

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11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia.PMID 8164041Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcomeSemantic proximity Read ↗

Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting ageSemantic proximity Read ↗

Acute lymphoblastic leukemias with deletion of 11q23 or a novel inversion (11)(p13q23) lack MLL gene rearrangements and have favorable clinical featuresSemantic proximity Read ↗

Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer GroupSemantic proximity Read ↗

Gene expression profiling–based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infantsSemantic proximity Read ↗

Treatment of infant leukemias: challenge and promiseSemantic proximity Read ↗

Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantationSemantic proximity Read ↗

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective studySemantic proximity Read ↗

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancySemantic proximity Read ↗

The distribution of <i><scp>MLL</scp></i> breakpoints correlates with outcome in infant acute leukaemiaSemantic proximity Read ↗

Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study GroupSemantic proximity Read ↗

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