Article
[Molecular diagnosis of Huntington's disease: an analysis of two large families].
Zhonghua yi xue za zhi - 1 Nov 1995
Zeng Y, Chen M, Mao Y
Abstract excerpt
At present molecular techniques comprise a main resource in the early accurate diagnosis for Huntington's disease. We describe the molecular diagnosis for 8 HD patients and 39 risky family members in two large HD pedigrees by using G8 RFLP linkage analysis as well as direct detection of the expan...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Base Sequence
- Child
- Child, Preschool
- DNA
- Female
- Humans
- Huntington Disease
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length