Article
Disease-induced natural selection in a diploid host.
Theoretical population biology - 1 Dec 1993
Andreasen V, Christiansen F B
Abstract excerpt
Using for each genotype an SIR-type model of disease transmission dynamics, we describe natural selection in a continuously breeding diploid host whose disease susceptibility and resistance are carried at one locus with two alleles. The system is transformed into variables that for each disease class describe the number of individuals, the gene frequency, and the deviation from Hardy-Weinberg proportions as...
Topics
- Alleles
- Birth Rate
- Communicable Diseases
- Diploidy
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Immunity, Innate
- Incidence
- Models, Genetic
- Selection, Genetic