Article
Impaired human tissue factor-mediated activity in blood clotting factor VIINagoya (Arg304-->Trp). Evidence that a region in the catalytic domain of factor VII is important for the association with tissue factor.
The Journal of biological chemistry - 11 Mar 1994
Matsushita T, Kojima T, Emi N, Takahashi I, Saito H
Abstract excerpt
A 37-year-old man was found to have an inherited abnormal factor VII (FVII) (designated FVIINagoya) that has a lower FVII procoagulant activity when tested in a one-stage assay using rabbit, simian, or human tissue factor (TF), but surprisingly has a nearly normal activity using bovine TF. DNA se...
Topics
- Adult
- Animals
- Arginine
- Base Sequence
- Binding Sites
- Blood Coagulation
- Catalysis
- Cattle
- DNA Primers
- Factor VII
- Factor X
- Humans
- Hydrolysis
- Male
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- Sequence Analysis, DNA