Article
Phenotype definition for genetic studies.
European archives of psychiatry and clinical neuroscience - 1 Jan 1993
Rice J P
Abstract excerpt
A difficulty in the interpretation of the reliability/stability of a lifetime diagnosis of mental disorders is the lack of a theoretical perspective. A model expressed in terms of the three unknowns-sensitivity, specificity and true base rate--is problematic due to the lack of a "gold standard", so that only two of these unknowns can be estimated. We extend this model to allow for clinical covariates that...
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