Article
Identification of repeat sequence heterogeneity at the polymorphic short tandem repeat locus HUMTH01[AATG]n and reassignment of alleles in population analysis by using a locus-specific allelic ladder.
American journal of human genetics - 1 Oct 1993
Puers C, Hammond H A, Jin L, Caskey C T, Schumm J W
Abstract excerpt
An allelic ladder containing amplified sequences of seven alleles of the polymorphic human tyrosine hydroxylase locus, HUMTH01, was constructed and employed as a standard marker. Sequence analysis of each ladder component indicates that fragments differ by integral multiples of the AATG core repe...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Gene Frequency
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic
- Racial Groups
- Repetitive Sequences, Nucleic Acid
- Tyrosine 3-Monooxygenase