Article
An MseI RFLP in the 5' flanking region of the factor IX gene: its use for haemophilia B carrier detection in Caucasian and Thai populations.
British journal of haematology - 1 May 1993
Winship P R, Nichols C E, Chuansumrit A, Peake I R
Abstract excerpt
We have identified an MseI restriction fragment length polymorphism (RFLP) in the 5' flanking region of the factor IX gene. RFLPs in the factor IX locus are routinely used as linkage markers to track defective factor IX genes through affected pedigrees, allowing diagnosis of the haemophilia B car...
Topics
- Alleles
- Base Sequence
- DNA
- Factor IX
- Female
- Genetic Carrier Screening
- Haplotypes
- Hemophilia B
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Thailand