A <i>Trypanosoma brucei brucei</i>‐Derived Factor that Triggers CD8⁺ Lymphocytes to Interferon‐γ Secretion: Purification, Characterization and Protective Effects <i>In Vivo</i> by Treatment with a Monoclonal Antibody against the Factor

Abstract excerpt

A protein factor that stimulates CD8+ lymphocytes to produce and secrete IFN-gamma has been purified from Trypanosoma brucei brucei (T.b. brucei). This was accomplished by raising monoclonal antibodies (MoAbs) against a fraction of T.b. brucei obtained by gel filtration, which contained high levels of material inducing rat mononuclear cells (MNC) to IFN-gamma production. MoAbs from four hybridomas strongly...

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