Article
Characterization of the von Willebrand factor gene (VWF) in von Willebrand disease type III patients from 24 families of Swedish and Finnish origin.
Genomics - 1 May 1994
Zhang Z P, Blombäck M, Egberg N, Falk G, Anvret M
Abstract excerpt
Twenty-four patients with von Willebrand disease type III were screened for mutations in the von Willebrand factor (VWF) gene using the PCR technique, followed by direct sequencing. More than 250 kb of genomic DNA were sequenced, including the promoter and coding regions (52 exons) of the VWF gen...
Topics
- Alleles
- Base Sequence
- DNA Mutational Analysis
- Exons
- Finland
- Gene Frequency
- Genes
- Genotype
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Repetitive Sequences, Nucleic Acid
- Sequence Deletion
- Sweden
- von Willebrand Diseases
- von Willebrand Factor