Article
Avoiding recomputation in linkage analysis.
Human heredity - 1 Jan 2000
Schäffer A A, Gupta S K, Shriram K, Cottingham R W
Abstract excerpt
We describe four improvements we have implemented in a version of the genetic linkage analysis programs in the LINKAGE package: subdivision of recombination classes, better handling of loops, better coordination between the optimization and output routines, and a checkpointing facility. The unifying theme for all the improvements is to store a small amount of data to avoid expensive recomputation of known...
Topics
- Algorithms
- Electronic Data Processing
- Genetic Linkage
- Genotype
- Humans
- Pedigree
- Recombination, Genetic
- Software