Article
alpha-1-Antitrypsin phenotypes among breast cancer patients in the Basque population.
Human heredity - 1 Jan 2000
García-Orad A, Arizti P, Durán L, Urcelay B, de Pancorbo M M
Abstract excerpt
One of the main functions of alpha 1-antitrypsin (A1AT) is to inhibit the activity of most proteases. It has been suggested that a deficiency in this protein may favor invasion by cancer cells--consequently, individuals with A1AT-deficient alleles (null, S and Z) may be at greater risk of tumoral invasion due to their lower capacity of response to proteolytic enzymes. This work examines the frequencies of A1AT...
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