Article
Low-dose enzyme replacement therapy for Gaucher's disease: effects of age, sex, genotype, and clinical features on response to treatment.
The American journal of medicine - 1 Jul 1994
Zimran A, Elstein D, Kannai R, Zevin S, Hadas-Halpern I, Levy-Lahad E, Cohen Y, Horowitz M, Abrahamov A
Abstract excerpt
Although alglucerase therapy has become the treatment of choice for symptomatic patients with Gaucher's disease, the low-dose/high-frequency regimen introduced as a means to reduce the high cost of treatment has raised major controversy. We evaluated the efficacy and safety of low-dose algluceras...
Topics
- Adolescent
- Adult
- Age Factors
- Child
- Child, Preschool
- Drug Administration Schedule
- Female
- Gaucher Disease
- Genotype
- Glucosylceramidase
- Humans
- Israel
- Liver
- Male
- Middle Aged
- Sex Factors