Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells.

Abstract excerpt

The integrity of the endothelial layer, which lines the entire cavity of the vascular system, depends on tight adhesion of the cells to the underlying basement membrane as well as to each other. It has been previously shown that such interactions occur via membrane receptors that determine the specificity, topology, and mechanical properties of the surface adhesion. Cell-cell junctions between endothelial cells,...

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