Article
Product binding modulates the thermodynamic properties of a Megasphaera elsdenii short-chain acyl-CoA dehydrogenase active-site mutant.
Biochemistry - 14 Jun 1994
Becker D F, Fuchs J A, Stankovich M T
Abstract excerpt
Previous work has shown that the redox properties of Megasphaera elsdenii short-chain acyl-CoA dehydrogenase (SCAD) are specifically modulated upon the binding of the substrate/product couple, allowing the reaction to proceed thermodynamically [Stankovich, M.T., & Soltysik, S. (1987) Biochemistry 26, 2627-2632]. The focus of this study on the Glu367Gln SCAD mutant protein is to gain an understanding of this...
Topics
- Acyl Coenzyme A
- Acyl-CoA Dehydrogenase
- Acyl-CoA Dehydrogenases
- Binding Sites
- Electrochemistry
- Mutation
- Oxidation-Reduction
- Protein Binding
- Thermodynamics