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Rapid Increases In Load Of Human Immunodeficiency Virus Correlate With Early Disease Progression and Loss of CD4 Cells in Vertically Infected Infants

1 Nov 1994

Abstract excerpt

The relationship between viral burden, timing of transmission, and clinical progression was investigated in 110 children at risk for vertical human immunodeficiency virus (HIV) infection using quantitative polymerase chain reaction, coculture, and immune complex-dissociated p24 antigen assay. In a cross-sectional study, the mean HIV DNA copy number in 19 symptomatic children was significantly higher than in 31...

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PMID: 7963727
DOI: 10.1093/infdis/170.5.1279

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