Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes mellitus.

Abstract excerpt

Non-insulin-dependent diabetes mellitus (NIDDM)' is pheno- typically heterogenous and may therefore not be explained by one simple pathophysiological mechanism. Despite the heterog- enous nature of the disease, the major form as discussed in this review is linked to overweight, arterial hypertension, dyslipidemia, and macroangiopathy (coronary heart disease), all condi- tions which become more common with aging...

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