Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene.

doi:10.1038/ng0894-531

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Article

Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene.

Nature genetics - 1 Aug 1994

Zhang L, Leeflang E P, Yu J, Arnheim N

Abstract excerpt

Trinucleotide repeat mutations of normal alleles at the human androgen receptor locus were studied by typing approximately 4,300 sperm. Control experiments established that the mutation events were of germline origin. The mutation rate for 20-22 repeat alleles was similar to that shown by family...

Topics

Alleles
Base Sequence
DNA Mutational Analysis
DNA Primers
Humans
Male
Minisatellite Repeats
Molecular Sequence Data
Mutation
Myotonic Dystrophy
Oligodeoxyribonucleotides
Polymerase Chain Reaction
Receptors, Androgen
Spermatozoa

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