A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal.

doi:10.1038/ng0894-497

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Article

A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal.

Nature genetics - 1 Aug 1994

Bardoni B, Zanaria E, Guioli S, Floridia G, Worley K C, Tonini G, Ferrante E, Chiumello G, McCabe E R, Fraccaro M

Abstract excerpt

Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute...

Topics

Chromosome Mapping
Dosage Compensation, Genetic
Female
Gene Deletion
Genetic Markers
Humans
Male
Multigene Family
Ovary
Phenotype
Sex Differentiation
Testis
X Chromosome

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