Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain.

Article

Histidine 326 is critical for the function of GLT-1, a (Na+ + K+)-coupled glutamate transporter from rat brain.

The Journal of biological chemistry - 29 Jul 1994

Zhang Y, Pines G, Kanner B I

Abstract excerpt

Removal of glutamate from the synaptic cleft is carried out by transporter molecules located in presynaptic nerve terminals and fine glial processes surrounding the cleft. Three such transporters, which are approximately 55% identical to each other, have recently been cloned. They catalyze electr...

Topics

Amino Acid Transport System X-AG
Animals
Biological Transport
Brain
Glutamates
Glutamic Acid
Glycoproteins
Histidine
Models, Molecular
Mutation
Potassium
Proteolipids
Rats
Sodium
Structure-Activity Relationship

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