Ethnic differences in the occurrence of the M1(ala213) haplotype of alpha-1-antitrypsin in asthmatic and non-asthmatic black and white South Africans.

doi:10.1111/j.1399-0004.1994.tb04008.x

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Article

Ethnic differences in the occurrence of the M1(ala213) haplotype of alpha-1-antitrypsin in asthmatic and non-asthmatic black and white South Africans.

Clinical genetics - 1 Mar 1994

Gaillard M C, Zwi S, Nogueira C M, Ludewick H, Feldman C, Frankel A, Tsilimigras C, Kilroe-Smith T A

Abstract excerpt

An ethnic study of 175 individuals, comprising 65 black and 110 white South Africans, has shown a conclusive difference in the frequency of the M1(ala213) haplotype of alpha 1-antitrypsin (P < 0.00001). The M1(ala213) haplotype occurred more frequently in the black group. In the latter group, the frequency of the M1(ala213) haplotype was the same in both controls (0.55) and asthmatics (0.53). However, there was a...

Topics

Adult
Alanine
Asthma
Base Sequence
Black People
Chi-Square Distribution
DNA Primers
Female
Gene Frequency
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Molecular Sequence Data

Pancreatic Elastase

Phenotype

Polymorphism, Restriction Fragment Length

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 7913005
DOI: 10.1111/j.1399-0004.1994.tb04008.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7913005-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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