Article
Immunohistochemical characterization of inflammatory cells and immunologic activation markers in muscle and nerve biopsy specimens from patients with systemic polyarteritis nodosa.
Arthritis and rheumatism - 1 Jul 1994
Cid M C, Grau J M, Casademont J, Campo E, Coll-Vinent B, López-Soto A, Ingelmo M, Urbano-Márquez A
Abstract excerpt
OBJECTIVE: To investigate the phenotype of infiltrating cells in classic lesions of polyarteritis nodosa (PAN). METHODS: Twenty-one muscle and 10 sural nerve biopsy samples from 24 patients with systemic PAN were studied using avidin-biotin-peroxidase and alkaline phosphatase-anti-alkaline phosphatase immunohistochemical techniques. RESULTS: The inflammatory infiltrates consisted mainly of macrophages (41%) and T...
Topics
- Adult
- Aged
- Biopsy
- CD4-CD8 Ratio
- CD4-Positive T-Lymphocytes
- Female
- Granulocytes
- Histocompatibility Antigens Class II
- Humans
- Immunohistochemistry