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Article

Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994

Kelly R J, Ernst L K, Larsen R D, Bryant J G, Robinson J S, Lowe J B

Abstract excerpt

The penultimate step in the biosynthesis of the human ABO blood group oligosaccharide antigens is catalyzed by alpha-(1,2)-fucosyltransferase(s) (GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase, EC 2.4.1.69), whose expression is determined by the H and Secretor (SE) blood group loci (also known as FUT1 and FUT2, respectively). These enzymes construct Fuc alpha 1-->2Gal beta-linkages, known as H...

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Source

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Identifiers

PMID: 7912436
DOI: 10.1073/pnas.91.13.5843
PMCID: PMC44093

Genes

ABO
FUT1
FUT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals.PMID 7912436Read ↗

Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles.Semantic proximity Read ↗

The H blood group system.Semantic proximity Read ↗

A new h allele detected in Europe has a missense mutationin alpha(1,2)-fucosyltransferase motif II.Semantic proximity Read ↗

A Bombay individual lacking H and Le antigens but expressing normal levels of alpha-2- and alpha-4-fucosyltransferases.Semantic proximity Read ↗

Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese.Semantic proximity Read ↗

Incidental Discovery of a Patient with the Bombay Phenotype.Semantic proximity Read ↗

Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme.Semantic proximity Read ↗

Heterogeneity of the human H blood group alpha(1,2)fucosyltransferase gene among para-Bombay individuals.Semantic proximity Read ↗

Two missense mutations of H type alpha(1,2)fucosyltransferase gene (FUT1) responsible for para-Bombay phenotype.Semantic proximity Read ↗

Point mutations and deletion responsible for the Bombay H null and the Reunion H weak blood groups.Semantic proximity Read ↗

FUT1 variants responsible for Bombay or para-Bombay phenotypes in a databaseSemantic proximity Read ↗

ABO phenotype-protected reproduction based on human specific α1,2 L-fucosylation as explained by the Bombay type formation.Semantic proximity Read ↗

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