Article
Molecular analysis of the glycoprotein C-negative phenotype of attenuated Marek's disease virus.
Virology - 1 Mar 1994
Wilson M R, Southwick R A, Pulaski J T, Tieber V L, Hong Y, Coussens P M
Abstract excerpt
Serial passage of oncogenic serotype 1 Marek's Disease virus (MDV) in cultured avian cells results in attenuation of viral oncogenicity and pathogenicity. Coincident with attenuation, expression of MDV glycoprotein C (gC) is significantly reduced. Regulation of MDV gC may have important implicati...
Topics
- Animals
- Antigens, Viral
- Base Sequence
- Cells, Cultured
- Ducks
- Gene Expression Regulation, Viral
- Genes, Viral
- Herpesvirus 2, Gallid
- Molecular Sequence Data
- Phenotype
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- RNA, Viral
- Serial Passage
- Transcription, Genetic
- Viral Envelope Proteins