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Article

Transposon-induced promoter scrambling: a mechanism for the evolution of new alleles.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Kloeckener-Gruissem B, Freeling M

Abstract excerpt

We have studied a germinal revertant of the Mutator (Mu3)-induced mutation (Adh1-3F1124) of the maize alcohol dehydrogenase 1 gene (adh1). Transposon Mu3 was inserted at the TATA box of the promoter. The excision of Mu3 caused a complex, multibreakpoint DNA rearrangement with deletion, inverted duplication, and inversions affecting 430 nucleotides in the promoter region. These changes led to an unusual pattern of...

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Identifiers

PMID: 7892187
DOI: 10.1073/pnas.92.6.1836
PMCID: PMC42377

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