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Article

Transposon-induced promoter scrambling: a mechanism for the evolution of new alleles.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 1995

Kloeckener-Gruissem B, Freeling M

Abstract excerpt

We have studied a germinal revertant of the Mutator (Mu3)-induced mutation (Adh1-3F1124) of the maize alcohol dehydrogenase 1 gene (adh1). Transposon Mu3 was inserted at the TATA box of the promoter. The excision of Mu3 caused a complex, multibreakpoint DNA rearrangement with deletion, inverted duplication, and inversions affecting 430 nucleotides in the promoter region. These changes led to an unusual pattern of...

Topics

Alcohol Dehydrogenase
Alleles
Biological Evolution
DNA Transposable Elements
Genes, Plant
Models, Genetic
Mutagenesis
Pollen
RNA, Messenger
Replication Origin
Sequence Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

TATA Box

Zea mays

Source

Open in PubMed Open full text

Identifiers

PMID: 7892187
DOI: 10.1073/pnas.92.6.1836
PMCID: PMC42377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7892187-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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